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Bertram Kjerulff¹, Henriette Thisted Horsdal², Kathrine Kaspersen³

¹Department of Clinical Immunology, Aarhus University Hospital, DK-8200, Aarhus N, Denmark; Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, Denmark; Department of Clinical Medicine, Aarhus University, Denmark.

Environmental research

|June 19, 2023

概括

暴露于空气污染,即使在低水平,也与增加C反应蛋白 (CRP) 水平有关,这是炎症的标志物. 这项关于丹麦献血者的研究发现了各种空气污染物和较高的CRP之间的联系.

科学领域:

环境健康环境健康
生物标志物生物标志物
流行病学流行病学

背景情况:

空气污染对全球疾病负担做出了重大贡献,导致肺和全身炎症.
C-反应蛋白 (CRP) 是炎症和疾病的关键生物标志物,与各种暴露有关.
之前对空气污染对低至中等污染环境中CRP的影响的研究产生了不一致的结果.

研究的目的:

调查暴露于各种空气污染物和C反应蛋白 (CRP) 水平之间的关联.
在一个低到中等空气污染环境中,对大量健康个体进行评估.
确定空气污染暴露是否与CRP升高有关,即使在空气看似干净的环境中也是如此.

主要方法:

一项涉及18463名丹麦献血者的横截面研究.
高灵敏度的CRP测量与模拟的空气污染数据 (NOx,NO2,O3,CO,SO2,NH3,颗粒物等) 有关. 在居住地址上.
使用有序后勤回归来分析关联,调整健康和社会经济共变量.

主要成果:

对大多数空气污染成分的暴露与更高CRP水平的可能性增加有关 (ORs 1.11-1.67).
具体来说,二氧化 (NO2) 暴露增加了高CRP的几率1.32倍 (95% CI 1.16-1.49).
对氨 (NH3) 的暴露与高CRP的几率降低有关 (OR 0.81,95% CI 0.73-0.89).

结论:

空气污染暴露与CRP水平升高有关,即使在污染低至中等的环境中也是如此.
这一发现突显了空气质量对一般健康人群炎症标志物的健康影响.
该研究强调了监测和减轻空气污染的重要性,以减少炎症性疾病的负担.

关键词:

空气污染大气污染暴露于空气污染的影响.献血者就是献血者.在C-反应性蛋白质中.横截面研究横截面研究环境对健康的影响

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