心理症状不会在有机功能性耐火性GERD谱线上的反流现象类型之间进行歧视
Annelies Geeraerts1, Livia Guadagnoli2, Ans Pauwels1
1Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.
Gut
|June 19, 2023
概括
心理症状在耐火患者的胃食道逆流性疾病 (GERD) 现型中没有差异. 这些发现表明,心理因素在整个GERD频谱中都很重要,而不仅仅是功能障碍.
科学领域:
- 胃肠病学 胃肠病学
- 心理学 心理学 心理学
背景情况:
- 从历史上看,心理过程与功能性胃食道逆流症 (GERD) 有关.
- 新兴研究表明,心理症状在整个GERD频谱中是相关的.
- 耐火性反流患者为研究这些关联提供了一个独特的队列.
研究的目的:
- 研究耐火性GERD患者的心理症状和反流现象类型之间的关联.
- 为了确定心理变量是否在GERD频谱表型中存在差异.
- 评估心理症状的预测价值,以确定反流表型成员的属性.
主要方法:
- 在393名耐火性反流患者中使用了pH阻抗监测和验证的问卷.
- 采用贝叶斯对差异的分析来比较不同类型的心理变量.
- 应用多项/顺序逻辑回归和机器学习来模型表型预测.
主要成果:
- 在GERD表型之间没有发现心理变量的显著差异.
- 年龄,性别和质子抑制剂的使用是显著的预测因素,BMI在回归模型中也很重要.
- 机器学习模型表现不佳,错误分类率高 (67-68%).
结论:
- 心理症状不能区分或预测耐火性GERD中的反流现型.
- 调查结果支持心理因素在GERD全谱中的相关性.
- 心理症状并不仅限于GERD中的功能性食道障碍.
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