在早期乳腺癌患者中,肥胖和循环瘤细胞之间的关联
Marie Tzschaschel1, Thomas W P Friedl1, Fabienne Schochter1
1Department of Gynecology and Obstetrics, University Hospital Ulm, Ulm, Germany.
Clinical breast cancer
|June 19, 2023
概括
肥胖和循环瘤细胞 (CTC) 与乳腺癌的不良结果有关. 这项研究发现患者的体重指数 (BMI) 或体重变化与CTC存在之间没有关联,这表明它们是独立的预后因素.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 临床试验 临床试验
背景情况:
- 肥胖和循环瘤细胞 (CTC) 是已知的乳腺癌 (BC) 的预后因素.
- 在脂肪组织中激活的致癌途径表明肥胖和CTC之间存在潜在的联系.
- 了解这种关系对于改善乳腺癌患者的治疗结果至关重要.
研究的目的:
- 调查身体质量指数 (BMI),化疗期间体重变化和乳腺癌早期患者中CTC存在的关联.
- 确定肥胖和CTC是否是乳腺癌的独立预后因素.
主要方法:
- 分析了来自第三阶段成功A试验的1088名早期乳腺癌患者的数据.
- 使用CellSearch系统评估循环瘤细胞 (CTC).
- 根据身体质量指数 (BMI) 和化疗期间体重变化对患者进行分类.
主要成果:
- 在化疗前或后的CTC阳性和BMI之间没有发现显著的关联 (分别P=0.104和P=0.051).
- 在化疗前或后的体重变化组和CTC状态之间没有观察到任何关联 (P=0.332).
- 在化疗前和化疗后的20.1%和22.6%的患者中检测到循环瘤细胞.
结论:
- 肥胖和循环瘤细胞 (CTC) 的患病率似乎是乳腺癌的独立预后因素.
- 该研究没有发现BMI或体重变化与乳腺癌患者的CTC之间存在关联.
- 需要进一步的研究来阐明肥胖和CTC在乳腺癌预后中的独立作用.
更多相关视频
14:14Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications
Published on: February 28, 2014
15.9K
05:17Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
Published on: May 14, 2019
8.7K
相关概念视频
01:24Obesity
549
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
549
02:17The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
02:07Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K