在人类疟疾感染中异常的寄生虫繁殖率
Megan A Greischar1, Lauren M Childs2
1Department of Ecology & Evolutionary Biology, Cornell University, Ithaca, NY, USA.
Trends in parasitology
|June 19, 2023
概括
在疟疾感染中量化寄生虫繁殖率 (PMRs) 的既定方法产生了不可思议的高结果. 这项研究揭示了采样偏差和感染期间变化的发育年龄如何膨胀这些关键的寄生虫指标.
科学领域:
- 疟疾学 疟疾学
- 寄生虫学的寄生虫学
- 传染病的动态传染病的动态.
背景情况:
- 致病生物体的快速繁殖率提高了传播,宿主损伤和药物耐药性的进化.
- 量化寄生虫繁殖率 (PMRs) 对于理解病原体动态至关重要,特别是在疟疾中.
- 疟疾PMR量化的现有方法被广泛使用,但可能会受到重大偏差的影响.
研究的目的:
- 批判性地评估用于量化疟疾寄生虫繁殖率 (PMRs) 的既定方法的准确性.
- 识别和解释当前PMR计算中高估的来源.
- 强调需要改善疟疾研究的方法.
主要方法:
- 对现代和历史人类疟疾感染数据的分析.
- 检查影响寄生虫采样的生物因素,包括发育阶段的可访问性.
- 模拟感染期间改变发育年龄分布的影响.
主要成果:
- 在疟疾感染中计算PMR的既定方法产生了异常且不可思议的大值.
- 膨胀的PMRs是由不同的寄生虫发育阶段的样本取样的不同易度造成的.
- 感染期间寄生虫发育年龄分布的变化进一步导致了高估.
结论:
- 准确量化疟疾寄生虫的繁殖率是当前标准方法的挑战.
- 这些发现需要开发更强大的PMR估计方法.
- 需要对疟疾现有知识进行重新评估,即使在PMR等研究得很好的方面也是如此.
相关概念视频
Symbiosis
29.0K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
29.0K
Diversity of Protists II
60
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
60


