在BA.5感染后,针对XBB Omicron亚型的中和抗体水平较低
Jingyun Yang1, Weiqi Hong1, Hong Lei1
1Laboratory of Aging Research and Cancer Drug Target, Department of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu, Sichuan, 610041, People's Republic of China.
Signal transduction and targeted therapy
|June 19, 2023
概括
来自Omicron BA.5感染的混合免疫力对较新的XBB亚变体具有有限的保护. 目前的COVID-19疫苗可能需要更新,以有效打击新出现的SARS-CoV-2菌株.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 由于Omicron亚型的特征,COVID-19应对策略的发展.
- 成都经历了一个BA.5-主导的SARS-CoV-2感染波.
- 评估对新型Omicron血统的混合免疫力至关重要.
研究的目的:
- 评估BA.5感染后混合免疫对新出现的Omicron亚变体 (XBB系) 的有效性.
- 研究疫苗接种史,年龄和性别对免疫反应的影响.
- 确定需要更新的COVID-19疫苗的需求.
主要方法:
- 从108名在BA.5浪潮中感染的参与者收集了血清和鼻.
- 对伪病毒的评估中和能力,包括XBB和XBB.1.5.5.
- 分析了幽默和细胞免疫反应.
主要成果:
- 康复者血清显示显著减少对XBB和XBB.1.5.5的中和.
- BA.5突破性感染仅对某些菌株提供了边际抗体增加.
- 尽管有混合免疫力,但对XBB血统的中和仍然很低.
结论:
- 目前来自BA.5感染的混合免疫力不足以对抗XBB亚变体.
- 迫切需要新一代的COVID-19疫苗,以XBB和未来的变种为目标.
更多相关视频
相关概念视频
00:42Cross-reactivity
31.3K
Overview
31.3K
01:22Development of Immunocompetence
366
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
366