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Updated: Jul 26, 2025

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC Crosslinking of Small Molecules to Isolate Chromatin
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多重-GAM:全基因组识别染色质接触产生了Hi-C忽略的见解

Robert A Beagrie1,2,3, Christoph J Thieme1, Carlo Annunziatella4

  • 1Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany.

Nature methods
|June 19, 2023
PubMed
概括

新的多重基因组架构映射 (GAM) 提供了一种更快,更实惠的方法来研究3D基因组拓. 这种无结的方法揭示了广泛的活跃基因组区域接触,这种接触往往被基于结的技术 (如Hi-C) 遗漏.

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Adaptation of Hybridization Capture of Chromatin-associated Proteins for Proteomics to Mammalian Cells

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Identification of Enhancer-Promoter Contacts in Embryoid Bodies by Quantitative Chromosome Conformation Capture 4C

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相关概念视频

Chromatin Immunoprecipitation- ChIP02:36

Chromatin Immunoprecipitation- ChIP

Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
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