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Updated: Jul 26, 2025

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在固体瘤中,c-Kit信号增强了CAR-T细胞的疗效,通过CD28和IL-2独立的共同刺激

Yuquan Xiong1, Meriem Taleb1, Kyohei Misawa1

  • 1Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature cancer
|June 19, 2023
PubMed
概括

通过利用c-Kit信号传递,针对固体瘤的工程化仿真抗原受体 (CAR) T细胞表现出更好的持久性和有效性. 这种新的方法可以在免疫抑制性瘤环境中增强T细胞功能.

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