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希尔的重叠生成方法的稳定性用于计算N_e到极端的生殖成功模式

Robin S Waples¹

¹School of Aquatic and Fishery Sciences, University of Washington, Seattle, WA, USA. robinw3@uw.edu.

|June 19, 2023

概括

希尔的有效人口大小 (N_e) 模型是强大的,即使有极端的繁殖模式,如斜和时间变化. 计算准确地预测了模拟中的遗传漂移率,为研究人员证明了其可靠性.

科学领域:

人口遗传学人口遗传学
进化生物学进化生物学
量化遗传学量化遗传学

背景情况:

有效的种群大小 (N_e) 对于理解遗传漂移和进化轨迹至关重要.
希尔模型是计算N_e的广泛使用的方法,它依赖于后代数的寿命差异.
之前的研究在稳定的年龄结构和恒定丰度假设下评估了Hill的模型.

研究的目的:

在极端繁殖成功场景下,评估希尔有效人口大小 (N_e) 模型的稳定性.
调查生殖倾斜,时间自相关性和生殖生存共差对N_e计算的影响.
评估Hill模型在模拟年龄结构人口中预测遗传漂移率的准确性.

主要方法:

在不同繁殖成功模式下的年龄结构人口中模拟基因漂移 (没有相关性,正相关性,负相关性).
引入了一个新的指数 (ρ_α,_α+) 来量化早期和终身生殖成功之间的相关性.
使用Hill的模型与实现的人口血统计算N_e,并将预测与模拟的遗传漂移率进行比较.

主要成果:

极端的生殖场景显著改变了后代数量的寿命差异,导致与基线相比N_e减少或增加.
新的索引 (ρ_α,_α+) 有效地捕获了模拟的生殖模式.
尽管存在极端情景,但当N_e从实现的血统中计算时,Hill的模型准确地预测了基因漂移率.

结论:

希尔的模型对极端的生殖成功模式表现出了显著的稳定性,包括高的生殖倾斜和时间变化.
基因漂移率的准确预测证实了希尔模型在各种生态环境中的实际实用性.
研究人员可以自信地应用希尔的模型来估计有效的人口规模,即使在处理复杂的繁殖动态.

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