微卫星稳定的结直肠癌的肺转移中的三级淋巴状结构
Topias Karjula1, Anne Niskakangas2, Olli Mustonen2
1Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Aapistie 5a, 90220, Oulu, Finland. topias.karjula@oulu.fi.
Virchows Archiv : an international journal of pathology
|June 19, 2023
概括
三级淋巴体结构 (TLS) 并没有预测结直肠癌 (CRC) 肺转移的结果,但在初级瘤中确实如此. 免疫细胞评分 (ICS) 在转移中更具预后性,与TLS相关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 三级淋巴体结构 (TLSs) 是慢性炎症和癌症中发现的免疫聚合物.
- TLS被认为是各种癌症的预后标记,包括结肠直肠癌 (CRC).
研究的目的:
- 调查TLS在CRC肺转移和原发性瘤中的预后意义.
- 将TLS的预后值与基于CD3+和CD8+T细胞密度的免疫细胞得分 (ICS) 进行比较.
主要方法:
- 在67个CRC肺转移和63个初级瘤中使用H&E染色分析了TLS密度和最大直径.
- 通过进行CD3和CD8免疫组织化学来评估ICS.
- 确保所有TLS测量的观测者之间达成优秀的协议.
主要成果:
- TLS密度和最大直径在CRC肺转移中没有预后价值.
- 在初级CRC瘤中,较高的TLS密度和最大直径与较低的死亡率有关.
- 与TLS相比,ICS在肺转移中的预后价值优于TLS,TLS和ICS之间存在显著的相关性.
结论:
- 在CRC肺转移中TLS缺乏预后价值,但与ICS相关.
- 初级CRC瘤中的TLS与良好的预后有关.
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