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Updated: Jul 26, 2025

Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids
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增强的BCAT1活性和BCAA代谢促进了癌症进展中的RhoC活性

Lin Qian1,2, Na Li1,2,3, Xiao-Chen Lu1,2

  • 1Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences; School of Basic Medical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; The Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College, Fudan University, Shanghai, China.

Nature metabolism
|June 19, 2023
PubMed
概括

分支链氨基酸转氨酶1 (BCAT1) 的特定突变通过促进氨基酸代谢和RhoC活性来增强癌细胞的生长和运动性. 坎德沙坦抑制了这种突变的BCAT1,为胃癌提供了潜在的治疗策略.

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