新生儿子宫出血是早期发生子宫内膜异位症的原因吗?
Kanae Ogawa1, Khaleque N Khan2,3, Haruo Kuroboshi1
1Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Reproductive biology and endocrinology : RB&E
|June 19, 2023
概括
新生儿子宫血液 (NUB) 似乎不会导致早期开始的子宫内膜异位症. 新生儿子宫内膜表现出增殖活性,但免疫细胞透率较低,可能允许盆腔中的细胞存活.
科学领域:
- 生殖生物学 生殖生物学
- 发育生物学是发展生物学.
- 妇科 妇科 妇科 妇科
背景情况:
- 早期开始的子宫内膜异位症的假设起源来自新生儿子宫血液 (NUB) 中的子宫内膜介质干细胞 (eMSC).
- 缺乏关联NUB/新生儿子宫内膜与早发性子宫内膜异位症的机制性理解.
研究的目的:
- 为了澄清NUB/新生儿子宫内膜和早期开始子宫内膜异位症的发展之间的机制联系.
主要方法:
- 分析死后新生儿子宫内膜 (n=15) 和NUB (n=18) 的生物标记物,包括eMSCs.
- 对新生儿子宫内膜的免疫组织化学分析,以发现类固醇受体,决定性标记物,增殖,血管性,免疫细胞和eMSC标记物.
- 在NUB中使用细胞转移和免疫细胞化学对eMSC和/或子宫内膜细胞的研究.
主要成果:
- 新生儿子宫内膜表现出可变的ER/PGR表达,树叶标记和显著的增殖/血管活动.
- 在新生儿和成人子宫内膜体中,甘氨酸A的表达均为中度至强度.
- 与成人子宫内膜相比,新生儿子宫内膜中CD56+,CD45+和CD68+免疫细胞的透率明显降低.
- 在NUB中没有检测到eMSC或子宫内膜细胞;然而,在新生儿子宫内膜中发现了一些eMSC表型 (CD90/CD105).
结论:
- 没有证据支持NUB在早期发生子宫内膜异位症中的作用.
- 新生儿子宫内膜中免疫能力较低的细胞积累可能有助于 ER+/PGR+细胞在骨盆中的存活.
- 需要进一步研究更大的样本大小和先进的技术来验证NUB假设及其意义.
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