在当前的甲基胺,大麻和酒精使用者中,COVID-19治疗结果没有差异
Ann Rydberg1, Christopher A Dodoo2, Terry D Schneekloth3
1Alix School of Medicine at Mayo Clinic, Phoenix, AZ, 58054, USA.
Journal of cannabis research
|June 19, 2023
概括
目前COVID-19的甲基胺 (METH),大麻和重酒精使用者表现出类似的治疗结果. 这些物质使用群体在感染后的一年内经历了高发病率,包括妄想和死亡率.
科学领域:
- 传染性疾病 传染性疾病
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 患有COVID-19和并发症的老年男性,包括物质使用障碍,往往有糟糕的结果.
- 目前使用甲基胺 (METH),大麻和重度酒精对COVID-19治疗结果的比较影响尚不清楚.
研究的目的:
- 调查和比较当前使用METH,大麻或重度酒精的患者中COVID-19治疗结果.
- 在COVID-19患者中识别与这些特定物质使用模式相关的发病率和死亡率的潜在差异.
主要方法:
- 对122名COVID-19患者 (32名METH,46名大麻,44名酒精使用者) 的电子医疗记录的回顾性审查.
- 通过PCR确认COVID-19,通过尿液检测确认目前的药物使用,通过血中酒精度通过重度酒精使用.
- 采用多变量回归模型来分析物质使用对治疗结果的影响.
主要成果:
- 在对共变量进行调整后,在ICU入院,停留时间,妄想,输管或死亡率方面,没有观察到物质使用组之间的显著差异.
- 在所有物质使用组中,发现了高比例的ICU入院 (15.2-21.9%) 和妄 (23.9-37.5%).
- 在SARS-CoV-2测试后10个月内死亡率在METH,大麻和酒精使用者群体中从4.3%到9.1%不等.
结论:
- 目前COVID-19的METH,大麻和重度酒精使用者表现出类似的高发病率和死亡率.
- 限制包括回顾性设计,小样本大小,缺乏对照组和未定量的物质使用.
- 需要进一步的研究来探索伴随性疾病的烟草吸烟对这些结果的影响.
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