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败血症的单细胞转录组分析识别出具有免疫抑制功能的HLA-DR低S100A高单细胞

Ren-Qi Yao1,2,3, Peng-Yue Zhao1,4, Zhi-Xuan Li1

  • 1Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of Chinese PLA General Hospital, Beijing, 100853, China.

Military Medical Research
|June 19, 2023
PubMed
概括

研究人员确定了一种新的单细胞子集,HLA-DR低S100A高,与败血症诱导的免疫抑制有关. 用Paquinimod阻断S100A9部分逆转了免疫抑郁症,为败血症管理提供了一个新的治疗策略.

关键词:
人类白细胞抗原DR (HLA-DR)免疫抑制是一种免疫抑制.单细胞 (Monocytes) 是一种单细胞.骨髓系衍生抑制细胞 (MDSCs) 是一种在Paquinimod中使用了Paquinimod.在S100A中,它是S100A.败血症 这是一种败血症.一个单细胞分析.

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