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生理盐对T1304和T1307化物的比较作用

Binny A Rudani¹, Jayant Sarolia^1,2, Ragini Rai¹

¹Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Raebareli, Lucknow, Uttar Pradesh 226002, India.

Langmuir : the ACS journal of surfaces and colloids

|June 20, 2023

概括

研究了Tetronics (T1304和T1307) 与生理盐的相互作用. 温度和盐分影响了性行为,T1304显示出比T1307.7更强的疏水效应.

科学领域:

合体和表面科学科学
聚合物化学聚合物化学
物理化学物理化学

背景情况:

泰特罗尼克是一种非离子表面活性剂,具有多种应用.
了解它们在生理盐溶液中的行为对于生物医学应用至关重要.
生理盐可以显著改变表面活性剂的聚合和特性.

研究的目的:

综合调查四氧化物 (T1304和T1307) 与各种生理盐的相互作用.
阐明盐和温度引起的热力学和微观结构变化.
了解盐类型和度对性聚合行为的影响.

主要方法:

度计,热度计和散射技术用于表征.
确定了化过程的热力学参数 (,).
进行了对四氧化物聚合物的微结构分析.
进行了云点和临界菌度 (CMC) 测量.

主要成果:

T1304形成了球形的核心外聚合物,而T1307存在于单体和大集群中.
盐的存在促进了T1307的化,顺序是:NaCl < KH2PO4 < NaH2PO4 ≪ Na2CO3.3.
聚合是内热的,由疏水性相互作用驱动 (TΔSmic > ΔHmic).
酸 (KI) 诱导了脱,增加了云点,CMC和自由能量.

结论:

与T1307相比,温度和盐对T1304产生更明显的疏水效应.
该研究提供了有关配方和输送系统的酸盐相互作用的见解.
疏水性相互作用是这些系统中性聚合的主要驱动力.

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