使用,原子和步骤经济 (PASE) 合成构建Octahydro-4H-cyclopenta[b]pyridin-6-one骨架
Silver Raju1,2, Palash Ghosh1,2, Kiranmai Nayani1,2
1Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India.
Chemistry (Weinheim an der Bergstrasse, Germany)
|June 20, 2023
概括
这项研究证明了使用级联反应有效合成复杂的多循环支架. 这些方法优先考虑,原子和步骤经济 (PASE) 以实现更绿色的化学合成.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
- 绿色化学 绿色化学
背景情况:
- 级联反应为复杂分子提供了高效的途径.
- ,原子和步骤经济 (PASE) 原则指导可持续合成.
- 循环加法反应是形成环的强大工具.
研究的目的:
- 开发用于多环架的新型合成路径.
- 将PASE原理应用于级联和循环加法反应.
- 在复杂分子合成中实现高的区域和 diastereoselectivity.
主要方法:
- 使用级联阿扎-皮安卡特利反应.
- 使用 [3+3] 和 [4+2] 循环加法反应.
- 实施,原子和步骤经济 (PASE) 合成策略.
主要成果:
- 成功生成了八水-4H-cyclopenta[b]pyridin-6-one支架的成功生成.
- 合成八水-5,7a-epoxycyclopenta[cd]异印醇-4-one框架,包括葡萄胺类化合物.
- 实现了一个新的decahydro-1H-dicyclopenta[cd,hi]isoindol-6-one.one的实现.
- 取得了良好的产量与优秀的区域和 diastereoselectivities.
结论:
- 开发的级联和循环添加反应对于合成复杂的多环结构是有效的.
- 通过成功地整合了PASE原则,从而实现了高效和选择性的合成.
- 该方法提供了访问有价值的类化合物框架和新型分子架构.
关键词:
级联反应是一种级联反应.基碳醇是一种基碳醇.易斯酸催化剂的作用八水-4H-cyclopenta[b]pyridin-6-one-one-pyridin-6-one-one-one-cyc[b]pyridin-6-one-one-cyc[b]pyridin-6-one-cyclopenta[b]pyridin-6-one-cyclopenta[b]pyridin-6-one-cyclopenta[b]pyridin-6-one-cyclopenta[b]pyridin-6-one-cyclopenta[b]pyridin-6-one-cyclopenta[b]pyridin-6-one-cyclopenta[b]pyridin-6-one-cyclopenta[b]pyridin-6-one-cyclopenta[b]pyridin-6-one-cyclopenta[b]pyridin-6-hydro-4H-cyclopenta[b]pyridin-6-one-cyclopenta[b]pyridin-6-hydro-4H-cyclopenta[b]pyridin-6-hydro-4H-cyclopenta[b]pyridin-6-one-cyclopenta[b]pyridin-6-hydro-4H-hydro-4H-hydro-4H-hydro-4H-hydro-4H皮亚卡特利反应 皮亚卡特利反应![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
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