在COVID-19时代管理IBD
Nicholas Scalzo1, Ryan C Ungaro2
1Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Department of Medicine Box 1118, New York, NY 10029-6574, USA.
Therapeutic advances in gastroenterology
|June 20, 2023
概括
患有炎症性肠病 (IBD) 的患者通常不会面临更高的COVID-19风险. 然而,年龄,类固醇使用和某些疗法等因素可能会增加并发症,需要量身定制的疫苗接种策略.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 2019年新冠肺炎疾病 (COVID-19) 的出现对全球健康产生了重大影响.
- 患有炎症性肠病 (IBD) 的患者通常免疫力受损,这引发了人们对他们的COVID-19风险的担忧.
- 在COVID-19大流行期间管理IBD患者的初始指导基于专家意见,因为风险不清楚.
研究的目的:
- 评估COVID-19在炎症性肠病患者中的特定风险和结果.
- 为了澄清IBD药物和疫苗接种策略的安全性和有效性,在COVID-19流行病的背景下.
主要方法:
- 对IBD患者COVID-19的新兴证据和专家意见的审查.
- 对IBD人口中与严重COVID-19结局相关的风险因素的分析.
- 评估IBD药物的安全性和疫苗的有效性.
主要成果:
- 压倒性的证据表明,IBD患者作为一个群体,没有增加严重COVID-19的风险.
- 诸如老年,类固醇使用,并发症,组合免疫调节疗法和活性IBD等因素与更糟糕的结果有关.
- 大多数IBD药物具有低风险,但例外包括某些免疫调节剂和组合疗法.
结论:
- IBD患者通常能很好地忍受COVID-19,但特定的风险因素需要注意.
- 接种疫苗对所有IBD患者都是安全有效的,对那些接受抗TNF治疗的人来说,可能需要增强剂.
- 持续监测和基于证据的管理对于IBD患者在传染病爆发期间至关重要.
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