简单的外周血液参数可能是预测胆囊炎严重程度和发病率的早期指标吗?
Sevda Yilmaz1, Muhammed Rasid Aykota1, Utku Ozgen1
1Department of General Surgery, Pamukkale University Faculty of Medicine, Denizli, Turkey.
Annals of surgical treatment and research
|June 20, 2023
概括
CRP/白蛋白比率 (CAR) 有效预测急性胆囊炎的严重程度和发病率,作为P-POSSUM得分的简单替代品. 这一发现有助于评估急性胆囊炎患者的疾病严重程度和预后.
科学领域:
- 医学诊断 医学诊断 医学诊断
- 炎症标志物是一种炎症标志物.
- 胃肠道疾病 胃肠道疾病
背景情况:
- 急性胆囊炎 (AC) 是一种常见的外科紧急情况.
- 准确评估AC严重程度和预测临床结果对于患者管理至关重要.
- 现有的评分系统可能很复杂,或者在某些临床环境中难以使用.
研究的目的:
- 评估中性粒细胞-淋巴细胞比率 (NLR) 和CRP/白蛋白比率 (CAR) 在评估AC疾病严重性的有效性.
- 确定NLR和CAR对AC患者临床结果的预测值.
- 将CAR与已建立的评分系统比较,例如P-POSSUM用于病率预测.
主要方法:
- 对被诊断患有急性胆囊炎的186名患者进行了回顾性分析.
- 基于东京指南的NLR,CAR,曼海姆炎指数 (MPI) 和P-POSSUM得分与AC严重程度等级的比较.
- 多变量分析以确定疾病严重程度和发病率的显著预测因素.
主要成果:
- 较高的CAR和MPI得分与中度至严重的AC (东京指南2-3级) 有关.
- CAR和P-POSSUM发病率得分与发病率的存在有显著的关联.
- 与轻度AC组 (26.7%) 相比,中度至重度AC组的发病率更高 (51.9%).
结论:
- CRP/白蛋白比率 (CAR) 是预测急性胆囊炎的严重程度的有价值和简单的参数.
- 在AC中预测病率时,CAR可以作为P-POSSUM得分的替代方案.
- 在AC中,NLR和CAR为评估疾病严重程度和预后提供了补充信息.
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