第四次mRNACOVID-19疫苗接种在患有血液恶性瘤的免疫功能低下患者中 (COBRA KAI):一个队列研究
Quincy Hofsink1,2, Sabine Haggenburg1,2, Birgit I Lissenberg-Witte3
1Department of Haematology, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
EClinicalMedicine
|June 20, 2023
概括
第四次mRNA COVID-19疫苗剂量改善了大多数血液癌症患者的抗体水平. 定时接种B细胞恢复疫苗可能会提高抗体质量,以获得更好的免疫反应.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 患有血液性恶性瘤的患者在接种SARS-CoV-2疫苗后表现出抗体反应减弱.
- 调查额外的mRNA疫苗剂量的疗效对于这种脆弱人群至关重要.
研究的目的:
- 评估第四次mRNACOVID-19疫苗接种是否提高了血液恶性瘤患者的抗体数量和质量.
- 为了比较免疫功能低下患者的免疫反应与年龄相匹配的健康个体.
主要方法:
- 一项队列研究涉及SARS-CoV-2天真,免疫功能低下的血液恶性瘤患者,接受4剂mRNA疫苗.
- 与健康对照对抗SARS-CoV-2变种 (野生型,Omicron BA.1,BA.4/5) 的抗体度和中和活性的比较.
- 使用世卫组织国际标准对结合抗体 (S1 IgG,N IgG) 的量化.
主要成果:
- 虽然第四剂量在大多数患者中改善了S1IgG度,但在第一次增剂后,水平仍然低于健康人群.
- 观察到中和抗体度显著上升,特别是在恢复B细胞的患者中.
- 尽管接种了四次疫苗,但19%的患者没有达到血清转化.
结论:
- 第四次mRNACOVID-19疫苗接种提高了大多数血液恶性瘤患者的抗体水平.
- 与B细胞恢复计时的疫苗接种策略可能会导致抗体反应质量的改善.
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