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在健康参与者中,abemaciclib没有增加纠正的QT间隔

Jill C Chappell1, Alan Y Chiang1, Jane Royalty2

  • 1Eli Lilly and Company, Indianapolis, Indiana, USA.

Clinical and translational science
|June 20, 2023
PubMed
概括

乳腺癌的CDK4/6抑制剂Abemaciclib在高达400mg的健康参与者中没有显著的QTc间隔变化. 高剂量增加了胃肠道副作用,表明在治疗水平上有良好的心脏安全性.

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