疟疾与酸水平降低有关:系统性审查和元分析
Manas Kotepui1, Aongart Mahittikorn2, Nsoh Godwin Anabire3,4
1Medical Technology, School of Allied Health Sciences, Walailak University, Thai Buri, Nakhon Si Thammarat, Thailand.
Antioxidants & redox signaling
|June 20, 2023
概括
与健康人相比,疟疾患者的 Askorbic 酸水平较低. 补充 Askorbic 酸可能有助于控制疟疾的进展,并通过恢复抗氧化剂平衡来减少疾病的严重程度.
科学领域:
- 生物化学 生物化学
- 传染性疾病 传染性疾病
- 营养科学 营养科学
背景情况:
- 阿斯科布酸水平与疟疾病原体之间的关系尚不清楚.
- 亚酸在抗氧化剂防御和免疫功能中起着至关重要的作用.
研究的目的:
- 系统地审查和综合有关疟疾患者酸水平的数据.
- 为了比较不同疟疾严重程度和Plasmodium物种的 Askorbic 酸水平.
主要方法:
- 在多个数据库 (PubMed,Embase,MEDLINE,Ovid,Scopus,Google Scholar) 中进行了系统的搜索.
- 来自30项涉及1480篇文章的研究数据使用随机效应模型进行了元分析.
- 计算了具有95%置信区间的标准化平均差异 (科恩的d).
主要成果:
- 疟疾患者的酸水平明显低于未感染的对照人群 (p < 0.01).
- 在严重和不严重的疟疾病例之间,没有发现阿斯科布酸水平的显著差异 (p = 0.06).
- 在Plasmodium falciparum和Plasmodium vivax感染 (p = 0.34) 之间,酸水平是可比的.
结论:
- 疟疾与酸水平降低有关.
- 营养干预措施,如酸补充剂,可以通过重新平衡氧化应激来提供一种改善结果和预防严重疟疾的策略.
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