用于诊断,治疗和治疗各种癌症的DNA水凝和纳米凝
Iman Zare1, Reza Taheri-Ledari2, Farhad Esmailzadeh2
1Research and Development Department, Sina Medical Biochemistry Technologies Co. Ltd., Shiraz 7178795844, Iran.
Nanoscale
|June 20, 2023
概括
脱氧核糖核酸 (DNA) 水凝为先进的癌症治疗药物输送提供可编程的3D支架. 本综述详细介绍了它们的准备,免疫反应和治疗疗法的应用,以改善治疗策略.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
- 癌症治疗方法 癌症治疗方法
背景情况:
- 脱氧核糖核酸 (DNA) 水凝,特别是纳米凝,正在成为有效的治疗药物输送系统.
- 它们作为3D支架的可编程性提供了显著的优势,特别是在癌症治疗应用中.
- DNA水凝可以与活性剂功能化,以增强向输送和修改治疗载荷的药理动力学.
研究的目的:
- 为设计和制备DNA水凝和纳米凝提供可行的方法的全面概述.
- 讨论免疫系统对基于DNA水凝的治疗货物的反应.
- 探索DNA水凝和癌症生物标志物之间的相互作用,包括神经学应用.
主要方法:
- 关于DNA水凝和纳米凝合成和制备技术的现有文献的审查.
- 对研究DNA水凝免疫性和生物相容性的研究进行分析.
- 对治疗剂的结合和对DNA水凝的向部分的研究进行审查.
- 讨论使用基于DNA纳米凝的系统检测癌症生物标志物的方法.
主要成果:
- DNA水凝具有可调节的特性,可以精确控制药物释放动力学和向.
- 免疫系统对DNA水凝的反应可以调节,从而影响治疗疗效和安全.
- 与癌症生物标志物的相互作用突出显示了诊断和治疗应用 (治疗术) 的潜力.
结论:
- DNA水凝代表了开发先进药物输送系统的多功能平台,特别是用于癌症治疗.
- 进一步研究它们的制备,免疫调节和超神能力将提高它们的临床转化.
- 可编程DNA纳米凝为综合癌症检测和治疗策略提供了有前途的途径.
相关概念视频
03:31Labeling DNA Probes
DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
02:34DNA Microarrays
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...