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在卵细胞冷保存后,一些表观遗传相关基因和microRNAs的表达模式的改变

Ali Shadmanesh¹, Hassan Nazari²

¹Reproductive Biotechnology in Veterinary, Islamic Azad University, Eqlid Branch, Iran.

Zygote (Cambridge, England)

|June 20, 2023

概括

卵细胞冷保存影响胚胎中的microRNA (miRNA) 表达和表观遗传特征. 了解这些变化对于评估辅助生殖技术后的生育保护和后代发育至关重要.

科学领域:

生殖生物学生殖生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
分子生物学分子生物学

背景情况:

微RNAs (miRNAs) 是卵细胞和胚胎中基因表达的关键调节者,对发育至关重要.
辅助生殖技术 (ART),包括卵细胞冷保存,可以改变miRNA表达并导致表观遗传变化.
这些ART诱导的改变对后代的长期影响尚未完全理解,这引发了人们的担忧.

研究的目的:

审查卵细胞冷保存对miRNA和表观遗传相关基因表达的影响.
评估不同的冷保存阶段,方法和冷保护剂 (CPA) 如何影响这些分子变化.
提高对冷卵子中的miRNA功能的理解,以改善胚胎发育和哺乳动物生育能力的保护.

主要方法:

对研究卵细胞冷保存及其对分子形状的影响的文献综述.
分析研究研究miRNA和表观遗传基因表达变化在卵细胞和胚胎后冷保存.
综合了与成熟前与成熟后冷保存和CPA效应相关的发现.

主要成果:

卵细胞的冷保存显然影响了miRNA的表达.
特定的冷保存方法和CPAs可以诱导产生的胚胎的表观遗传变化.
微RNA表达的变化与冷保存时间 (成熟前与成熟后) 有关.

结论:

卵细胞冷保存影响了miRNA表达和表观遗传景观.
需要仔细考虑冷保存技术和CPA,以减轻潜在的风险.
需要进一步的研究才能充分阐明对胚胎发育和后代健康的后果.

关键词:

结冷保存是一种冷保存.在表观遗传学上,表观遗传学是表观遗传学.哺乳动物哺乳动物这是一个微型RNA.卵细胞是卵细胞中的一个.

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