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相关概念视频

RNA Structure01:23

RNA Structure

71.7K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
71.7K
Protein Folding Quality Check in the RER01:29

Protein Folding Quality Check in the RER

3.8K
ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
3.8K
RNA-seq03:21

RNA-seq

10.1K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
10.1K
Nucleic Acid Structure01:25

Nucleic Acid Structure

6.2K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
6.2K

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相关实验视频

Updated: Jul 26, 2025

RNA Secondary Structure Prediction Using High-throughput SHAPE
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RNA Secondary Structure Prediction Using High-throughput SHAPE

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C-RCPred:一种多目标算法,用于对RNA复合体的交互式二次结构预测,集成用户知识和SHAPE数据.

Mandy Ibéné1, Audrey Legendre1, Guillaume Postic1

  • 1Université Paris-Saclay, Univ Evry, IBISC, 91020, Evry-Courcouronnes, France.

Briefings in bioinformatics
|June 20, 2023
PubMed
概括

预测RNA复杂结构是一个挑战. 一个新的工具,C-RCPRed,使用用户知识和探测数据与一个多目标算法,以改善预测多RNA复合体.

关键词:
多目标算法多目标算法在RNA复合体中,RNA复合体预测RNA结构 预测RNA结构形状数据 形状数据

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科学领域:

  • 计算生物学 计算生物学
  • 生物信息学是一种生物信息学.
  • 分子生物学分子生物学

背景情况:

  • RNA分子与各种环境因素 (如离子,蛋白质和其他RNA) 相互作用,形成具有关键生物功能的复合体.
  • 预测这些RNA复合物的结构,特别是涉及多个相互作用RNA的结构,是分子生物学中的一个重大挑战.

研究的目的:

  • 开发和评估一种用于预测由两个以上相互作用的RNA分子组成的RNA复合体的二次结构的计算工具.
  • 研究将有关单个RNA和实验探测数据的现有知识纳入结构预测过程的实用性.

主要方法:

  • 开发C-RCPRed,一个使用多目标优化算法的交互工具.
  • 将用户提供的知识和探测数据 (实验或人工) 集成到预测工作流中.
  • 与最先进的方法进行广泛的比较,以评估预测效率.

主要成果:

  • 证明RNA复杂结构预测的多目标优化方法的有效性.
  • 量化结合用户知识和探测数据对预测准确性的积极影响.
  • 通过全面的基准测试验证C-RCPRed的业绩.

结论:

  • 通过利用用户知识和探测数据,C-RCPRed工具提高了多RNA复杂二次结构的预测能力.
  • 多目标优化是解决复杂的RNA结构预测问题的有效策略.
  • 作为一个开源程序和Web服务器,C-RCPRed是可用的,促进RNA结构生物学更广泛的研究.