在压力期间比较雷加多诺森和二皮里达摩尔的安全性概况心肌输血成像
Jan Roczniak1, Justyna Bączalska1, Gabriela Kanclerz1
1Jagiellonian University Medical College, Students' Scientific Group Medical Imaging in Cardiology, Kraków, Poland.
Molecular imaging and radionuclide therapy
|June 20, 2023
概括
在心脏成像过程中,雷加дено松和二皮里达摩尔的副作用率相似. 瑞格达诺松导致血压下降较小,提高了药理应力测试中的患者安全.
科学领域:
- 心脏病学 心脏病学
- 诊断成像 诊断成像 诊断成像
- 药理学 药理学是指药理学的学科.
背景情况:
- 使用血管扩张剂的药理应力测试对于无法接受运动应力测试的患者的心肌输液成像 (MPI) 至关重要.
- 雷加登和二皮里达摩尔是用于SPECT MPI的常用血管扩张剂.
研究的目的:
- 为了比较SPECT MPI期间雷加登和二皮里达摩尔之间的副作用的频率和严重程度.
- 评估这些药物对血压参数的影响.
主要方法:
- 对283名接受药理应力测试的患者 (2015-2020年) 的回顾性分析.
- 收集的数据包括患者的特征,轻度/重度副作用的发生,以及血压测量.
- 在接受二皮里达摩尔的240名患者和接受雷加代诺松的43名患者之间进行了比较.
主要成果:
- 整体并发症的发生率相似:雷加代诺的23.2%和二皮里达摩尔的26.7% (p=0.639).
- 两种药物之间在轻度或重度并发症患病率上没有发现显著差异.
- 与二皮里达摩尔相比,雷加德诺松导致静脉血压 (SBP),静脉血压 (DBP) 和平均动脉压 (MAP) 的平均降低明显较小.
结论:
- 在SPECT MPI期间,雷加登和二皮里达摩尔在副作用频率方面表现出相似的安全概况.
- 由于SBP,DBP和MAP的减少不那么明显,雷加登显示出优越的血液动力学安全概况.
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