摩拉低矿化,参与膜发育的基因和儿童早期药物治疗之间的关联:初步研究
Fernanda Mafei Felix da Silva1, Flávia Martinez de Carvalho2, Ana Luiza Meneguci Moreira Franco2
1Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
International journal of paediatric dentistry
|June 20, 2023
概括
儿童早期的药物使用,特别是在前四年内,与菌低矿化 (MH) 有关. 特定的基因变异,如KLK4 rs2235091,也可能影响这种疾病的发展.
科学领域:
- 遗传学 是一个遗传学.
- 儿科牙科 儿科牙科
- 发展生物学 发展生物学
背景情况:
- 毛低矿化 (MH) 是一种多因素的牙缺陷.
- 它的病因涉及遗传倾向和环境因素之间的复杂相互作用.
研究的目的:
- 调查摩尔低矿化 (MH) 之间的关联.
- 为了检查特定的膜发育基因 (AMBN,ENAM,KLK4) 在MH中的作用.
- 评估怀孕和幼儿期药物使用对MH发育的影响.
主要方法:
- 一项涉及118名儿童的病例控制研究 (54名患有MH,64名没有).
- 使用实时PCR对AMBN,ENAM和KLK4基因多态的遗传分析.
- 收集人口,社会经济和详细的病史,包括药物使用情况.
主要成果:
- KLK4 rs2235091 变异基因基因表现出与 MH 的显著关联 (OR:3.75,p=0.001).
- 在生命的前四年中使用药物与MH有关 (OR:2.94,p=0.041).
- 在ENAM,AMBN和KLK4中观察到药物使用和多态性之间的相互作用 (p<0.05).
结论:
- 产后药物摄入似乎是导致某些儿童MH病因的一个因素.
- 基因KLK4基因的遗传变异可能在菌低矿化发展中发挥作用.
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