一个全面的回顾转皮体作为一种新的膀式方法,通过透皮途径传递药物
Minahal Munir1, Muhammad Zaman1, Muhammad Ahsan Waqar1
1Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, Pakistan.
Journal of liposome research
|June 20, 2023
概括
通过改善皮肤透度,转基因组 (TEs) 增强了通过皮肤传递的药物. 这些超可变形囊泡 (UDVs) 提供了一种非侵入性的方法来提供各种药物,增加患者的服药性.
科学领域:
- 制药科学 制药科学
- 生物技术是生物技术.
- 皮肤病学 皮肤病学
背景情况:
- 通过皮肤递送的药物在口服途径上具有优势,但在角层透方面面临挑战.
- 超可变形囊泡 (UDVs),包括转基因组 (TE),基因组和转基因组,代表了一种克服皮肤屏障限制的新方法.
- 晶体体体,以其独特的乙醇,脂和边缘激活剂组成,表现出增强的弹性,以改善药物透.
研究的目的:
- 审查膀式方法,以克服通过皮肤递送药物的障碍.
- 详细介绍转基因组 (TE) 的组成,制备方法和表征.
- 探索皮肤透的机制和TE的各种医疗应用.
主要方法:
- 使用冷,热,薄膜水化和乙醇注射等方法制备TE.
- 包括pH值,大小,形状,泽塔潜力,药物含量和稳定性在内的TE的表征.
- 在体外皮肤透研究以评估药物透效率.
主要成果:
- 由于其组成和弹性,TEs通过角层表现出改善的药物透.
- 不同的制备技术产生了适合通过皮肤递送药物的TEs.
- 鉴定证实了TEs的物理和化学特性,以便有效的药物加载和释放.
结论:
- 转基因组是有效的超可变形囊泡,可以增强通过皮肤递送药物.
- 它们的非侵入性改善了患者的坚持和遵守.
- 试验体显示出提供广泛治疗剂的潜力,包括止痛药,抗生素和抗癌药物.
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