控制营养状况 (CONUT) 评分作为胃肠道 stromal 瘤的预后标记
Chao Sui1, Chen Lin2, Tingting Tao1
1Department of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
ANZ journal of surgery
|June 20, 2023
概括
控制营养状况 (CONUT) 评分预测了胃肠瘤患者的结果. 较高的CONUT分数表明预后较差,建议将其用作预后标记.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 营养科学 营养科学
背景情况:
- 控制营养状况 (CONUT) 评分是患者营养状况和各种癌症预后的公认指标.
- 特别是对于胃肠道层瘤 (GISTs) 的CONUT得分的预后价值尚未得到充分确立.
研究的目的:
- 调查CONUT得分与GIST患者的预后之间的关联.
主要方法:
- 对355名经过手术切除的GIST患者进行了回顾性分析.
- 使用接收器运行特征 (ROC) 曲线分析确定CONUT分数截止值.
- 使用Kaplan-Meier分析和Cox比例危险模型评估无复发生存率 (RFS) 和整体生存率 (OS).
主要成果:
- 确定CONUT得分的最佳切断值为3 (曲线下的面积=0.638).
- 较高的CONUT分数与较差的RFS和OS有显著的关联.
- 多变量分析证实CONUT得分是RFS和OS的独立风险因素,无论患者的人口统计和瘤特征如何.
结论:
- 在手术治疗的GIST患者中,CONUT评分是预后的新和有效预测指标.
- 在GIST的综合管理中,CONUT得分有可能成为一个有价值的预后标记.
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
362
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
362
02:07Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
01:26Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
114
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
114