在艾滋病毒感染者中评估下骨状骨的微型架构
Sunil Wadhwa1, Michael Levit1, Satoko Matsumura2
1Division of Orthodontics, Columbia University College of Dental Medicine, New York, New York, USA.
Oral diseases
|June 20, 2023
概括
与艾滋病毒感染者 (PLWH) 相比,患有艾滋病毒的人表现出更密集的下冠状骨结构,特别是肌厚度和骨体积分数增加,与HIV阴性个体相比. 这项研究研究了PLWH的面骨变化.
科学领域:
- 口腔和面放射学 口腔和面放射学
- 艾滋病毒/艾滋病研究研究
- 骨生物学 骨生物学 骨生物学
背景情况:
- 艾滋病毒感染者 (PLWH) 在轴骨和尾骨的骨矿物质密度降低.
- 艾滋病毒对面骨微型架构的影响在很大程度上仍未被探索.
- 状状骨的变化可能会影响PLWH中关节 (TMJ) 的健康.
研究的目的:
- 为了研究 PLWH 中下尾骨的骨微型结构.
- 为了比较PLWH和HIV阴性对照之间的面骨表型.
- 评估艾滋病毒状态和关节骨关节炎 (TMJD-OA) 之间的潜在关联.
主要方法:
- 招募了212名参与者 (124名PLWH,88名HIV阴性对照).
- 通过验证的TMD疼痛查问卷和圆束计算机断层扫描 (CBCT) 收集的数据.
- 进行了定性TMJD-OA评估和定量下带骨微架构分析.
主要成果:
- 两组之间自我报告的TMD或放射性TMJD-OA没有显著差异.
- 艾滋病毒阳性状况与椎骨厚度增加相关.
- 艾滋病毒阳性状况与皮层孔隙性降低和皮层骨体积分数增加有关.
结论:
- 与艾滋病毒阴性个体相比,PLWH显示下带状骨密度提高.
- 增加椎骨厚度和皮质骨体积分数是PLWH的关键发现.
- 艾滋病毒状况影响下骨状骨的微架构,独立于TMJD-OA.
相关概念视频
01:55Bone Structure
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
01:27Compact Bone
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...