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巴库基醇通过调节瘤微环境和PD-L1的表达来抑制肺癌

Mengxin Lin^1,2,3, Qian Xu¹, Yang Luo¹

¹Department of Oncology, Fujian Medical University Union Hospital, Fuzhou, China.

Journal of biochemical and molecular toxicology

|June 20, 2023

概括

巴库基醇 (BAK) 是一种来自植物的化合物,通过促进细胞毒性免疫细胞和降低PD-L1表达的调节,有效地抑制了肺癌的生长. 这表明BAK是BAK.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
在瘤学瘤学.

背景情况:

免疫检查点治疗是一种有前途的癌症治疗方法.
需要新的治疗化合物来增强免疫检查点疗法.
巴库基醇 (BAK) 是一种草药衍生化合物,具有潜在的抗癌特性.

研究的目的:

为了研究Bakuchiol在治疗肺癌中的有效性.
为了确定Bakuchiol是否可以调节编程死亡连接体1 (PD-L1) 的表达.
阐明Bakuchiol抗癌作用背后的机制.

主要方法:

建立了一个小鼠易斯肺癌 (LLC) 模型.
小鼠接受了15天的不同剂量的Bakuchiol (5-40 mg/kg) 治疗.
分析了免疫细胞群 (CD4+,CD8+T细胞,Treg细胞,M1/M2巨细胞),细胞因子水平,PD-L1表达和AKT/STAT3信号传递.

主要成果:

不管治疗的开始时间,Bakuchiol显著抑制了LLC瘤的生长.
BAK治疗增加了细胞毒性免疫细胞 (CD8+ T细胞,M1巨细胞) 和减少了前瘤细胞 (CD3+ T细胞,Treg细胞,M2巨细胞).
巴库基醇上调抗炎细胞因子和下调PD-L1表达,同时抑制AKT和STAT3信号传递.

结论:

在小鼠模型中,Bakuchiol在减少肺癌生长方面表现出显著的有效性.
BAK作为PD-L1抑制剂,抑制AKT和STAT3信号通路的作用.
这些发现支持Bakuchiol作为肺癌治疗新型治疗剂的潜力.

关键词:

在 AKT AKT 里面.在PD-L1中.在STAT3中,我们可以使用STAT3.巴库奇奥尔是什么意思肺癌是一种肺癌.

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