在患有甲状腺功能障碍的儿科患者中,对眼外肌肉的声谱表征
Kelly H Yom1, Brittany A Simmons2, Liuska M Pesce3
1Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Orbit (Amsterdam, Netherlands)
|June 20, 2023
概括
轨道声谱显示,在患有甲状腺功能障碍的儿童中,眼外肌肉 (EOMs) 扩大,特别是升高-上直肠综合体. EOM大小与老年儿童的疾病活性相关,有助于儿童甲状腺眼部疾病的评估.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
背景情况:
- 甲状腺眼病 (TED) 影响所有年龄段的人,但儿科表现和诊断标准需要具体的描述.
- 眼外肌肉 (EOM) 尺寸变化是成年人TED的标志,但儿童群体的数据有限.
研究的目的:
- 在患有甲状腺功能障碍的儿科患者中建立对EOM大小的超声波参考范围.
- 调查TED儿童中EOM大小,临床活性评分 (CAS) 和甲状腺刺激免疫球蛋白 (TSI) 之间的相关性.
主要方法:
- 对20名患有甲状腺功能障碍的儿科患者 (<18岁) 的回顾性分析,这些患者接受了轨道声谱.
- 测量直径肌肉厚度,并与儿科患者确定的正常范围进行比较.
- 按年龄队列分层 (5-10岁和11-17岁) 用于与CAS和STI进行相关性分析.
主要成果:
- 在所有年龄组的甲状腺功能障碍儿童中,上升直肠综合体显著扩大 (p < .004),在78%的眼睛中观察到.
- 与成人TED相比,在儿科TED中,EOM扩大更频繁.
- 临床活动分数 (CAS) 与EOM大小相关,在较大的儿童 (11-17岁,p < .027) 中,但在较小的儿童 (5-10岁,p > .315) 中没有相关.
- 甲状腺刺激性免疫球蛋白 (TSI) 在任何年龄组中都没有与EOM大小显著相关 (p > .206).
结论:
- 确定了儿科甲状腺功能障碍中EOMs的声谱参考范围.
- 在患有TED的儿童中,上方直肠复合体常常会扩大.
- EOM大小作为疾病活动的潜在指标,特别是在老年儿科患者中,补充临床评估.
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