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相关概念视频

Motor Unit Stimulation01:20

Motor Unit Stimulation

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When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
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Engineering Platform and Experimental Protocol for Design and Evaluation of a Neurally-controlled Powered Transfemoral Prosthesis
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可注射的腹脊椎刺激器唤起可编程和生物模拟的后肢运动.

Dingchang Lin1,2,3,4,5, Jung Min Lee5,6, Chonghe Wang5

  • 1Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.

Nano letters
|June 20, 2023
PubMed
概括
此摘要是机器生成的。

在小鼠体内植入了一种新型的,薄薄的脊髓刺激器,以最少的入侵方式恢复了后肢运动. 这种灵活的设备精确地准运动神经元,为脊髓损伤和神经运动疾病提供了改善的功能.

关键词:
生物电子学 生物电子学epidural 带外围电刺激脊髓损伤导致的脊髓损伤脊椎界面是脊椎界面.腹侧植入式植入式植入

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A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation
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Bilateral Assessment of the Corticospinal Pathways of the Ankle Muscles Using Navigated Transcranial Magnetic Stimulation
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相关实验视频

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科学领域:

  • 生物医学工程 生物医学工程
  • 神经科学是一个神经科学.
  • 再生医学是一种再生医学.

背景情况:

  • 脊髓神经调节显示出在受伤或疾病后恢复运动功能的前景.
  • 现有的脊柱刺激器面临着局限性,包括低于最佳的放置和侵入性手术要求.

研究的目的:

  • 开发和评估一种新的,灵活的,可伸缩的脊柱刺激器,用于微创植入.
  • 在小鼠模型中评估本装置在恢复运动功能的有效性.

主要方法:

  • 设计了一种纳米级薄,灵活的脊柱刺激器,并通过导管植入小鼠的腹腔脊柱空间.
  • 刺激值电流和机动池招募在腹侧外围植入物和背侧外围植入物之间进行了比较.
  • 使用特定的刺激模式来引起后肢运动.

主要成果:

  • 与背外皮外腔植入器相比,腹侧植入器显示了显著较低的刺激值和更精确的机动池招募.
  • 刺激器成功诱导了功能相关和新的后肢运动.
  • 最少侵入性的植入技术被证明是有效的.

结论:

  • 这种灵活的,可注射的脊柱刺激器为当前的神经调节技术提供了一个有前途的替代方案.
  • 腹侧侧的方法提高了刺激效率和运动控制.
  • 这项技术在治疗脊髓损伤和神经运动障碍方面具有显著的翻译潜力.