基于跨种族和民族群体初步生物标志物评估的严重COVID-19风险估计
Martin H Kroll1, Caixia Bi2, Ann E Salm3
1From the Department of Medical Operations and Quality (Kroll), Quest Diagnostics, Secaucus, New Jersey.
Archives of pathology & laboratory medicine
|June 20, 2023
概括
早期预测COVID-19的严重程度至关重要. 关键的生物标志物如年龄,白蛋白和费里丁可以帮助在初始诊断时识别严重病例,帮助及时治疗.
科学领域:
- 医学研究 医学研究
- 传染病流行病学 传染病流行病学
- 发现生物标志物的发现.
背景情况:
- COVID-19呈现出疾病严重程度的广泛范围.
- 早期预测疾病严重程度对于适当的患者管理至关重要.
- 在初始诊断时,关于预测因素的数据有限.
研究的目的:
- 开发COVID-19严重程度的预测模型.
- 利用最初与患者接触的人口统计,临床和实验室数据.
- 确定区分严重和轻度COVID-19结果的关键预测因素.
主要方法:
- 对14147名COVID-19患者的非识别数据进行了回顾性分析.
- 后向步骤逻辑回归建模. 后向步骤逻辑回归建模.
- 在诊断时包括人口,临床和实验室变量.
主要成果:
- 为COVID-19严重程度开发了四种熟练的预测模型.
- 在模型中一致识别的关键预测因子包括年龄,白蛋白,透缩血压,费里丁,乳酸脱酶,社会经济地位,公素,B型尿素和血小板数.
- 18%的患者经历了严重的结果,24%的患者经历了轻微的结果.
结论:
- 在特定和敏感模型中识别的生物标志物对初始COVID-19严重程度评估有价值.
- 这些发现可以帮助医疗保健提供者进行早期评估和管理决策.
- 这项研究强调了易于获得的数据对于预测疾病轨迹的有用性.
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