一个新的应变能量功能,代表了心肌的被动行为
Tawfik M Hussein1, John C Criscione1
1Department of Biomedical Engineering, Texas A&M University, College Station 77843-3120, TX.
Journal of biomechanical engineering
|June 20, 2023
概括
一个新的Criscione-Hussein模型显著改善了被动心肌 (心肌) 机制的预测. 与较旧的Fung和Holzapfel-Ogden模型相比,这种模型减少了计算时间和不确定性.
科学领域:
- 生物力学 生物力学
- 计算生物学 计算生物学
- 材料科学 材料科学 材料科学
背景情况:
- 经典的被动心肌模型 (,霍尔扎菲尔-奥格登) 显示了诸如高退化率和数学约束等局限性.
- 这些局限性阻碍了它们在微观结构实验和用于心脏组织分析的精密医学中的应用.
研究的目的:
- 开发一种新,强大的心肌动脉被动行为的模型.
- 解决计算和实验心脏力学现有模型的局限性.
主要方法:
- 杆式上方三角形 (QR) 分解和直角变量属性.
- 开发了一个可分离的应变能量函数,用于新的Criscione-Hussein模型.
- 通过左心肌的公布双轴数据验证了模型.
主要成果:
- 克里西诺-侯赛因模型显示,不确定性和计算时间显著减少 (p < 0.05).
- 与Fung和Holzapfel-Ogden模型相比,观察到材料参数的可靠性提高.
- 获得了被动心肌行为预测能力的提高.
结论:
- 克里西诺-侯赛因模型为被动心肌力学提供了更好的可预测性.
- 这种新模型可以更准确地计算心脏力学模型.
- 它使得更好的可视化和实验连接到心肌微观结构.
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