基于纳米酶的guanidinium片介导了表面反应性氧物种,用于多药耐药细菌感染管理
Xufeng Zhu1,2, Qiang Sun1,2,3, Jinjun Chen1,2,3
1The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong, 524023, China. jincanchen@126.com.
Journal of materials chemistry. B
|June 20, 2023
概括
改性氧化物纳米酶 (SBI NPs) 显示出增强的抗菌活性和降低的毒性. 这些新型纳米酶有效治疗肺部感染并促进伤口愈合,在后抗生素时代提供了一个有希望的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 传染性疾病 传染性疾病
背景情况:
- 纳米酶是有前途的抗菌剂,但面临着低效率和毒性等挑战.
- 开发具有改进向和减少副作用的新型纳米酶至关重要.
研究的目的:
- 为了合成和表征瓜尼迪尼-贝他因改性氧化物纳米酶 (SBI NPs).
- 评估SBINP的抗菌疗效,准能力和细胞毒性.
- 评估SBI NP对MRSA肺部感染和糖尿病伤口愈合的in vivo治疗潜力.
主要方法:
- 一氧化纳米颗粒 (IrONP) 的水热合成.
- 用瓜尼尼-贝他因 (SNLP/BS-12) 修改IrONP的表面,以形成SBINP.
- 在体外抗菌检测,哺乳动物细胞的细胞毒性测试.
- 关于MRSA急性肺部感染和糖尿病伤口愈合模型的体内研究.
主要成果:
- 与未经修改的IrONP相比,SBINP表现出增强的细菌向和改善的催化活性.
- SBI NPs对哺乳动物细胞的细胞毒性显著降低.
- 在体内实验表明,SBI NPs有效地缓解了MRSA急性肺部感染,并促进了糖尿病伤口愈合.
结论:
- 瓜尼尼的功能化增强了氧化纳米酶的抗菌性质和安全性.
- SBI NPs代表了一种具有治疗潜力的强效和低毒性抗菌剂.
- 这些发现表明SBI NPs是抗生素后时代对抗感染的有希望的抗生素候选者.
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