在加的松鼠中喉群和抗菌耐药性
Johanna P Wiethoff1,2,3, Sarah Sandmann4, Tom Theiler5
1Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
Microbiology spectrum
|June 20, 2023
概括
野生加松鼠可以携带与人类有关的抗微生物耐药细菌,包括扩展谱β-乳糖酶 (ESBL) 生产的Klebsiella pneumoniae和Escherichia coli. 这突显了潜在的公共卫生问题,特别是野肉消费普遍存在的地方.
科学领域:
- 微生物学 微生物学
- 动物传播疾病 动物传播疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 野生动物作为动物感染病原体的水库.
- 鱼被研究为潜在的病毒存储库,如SARS-CoV-2.
- 野生动物中抗微生物药物耐药细菌的存在是一个日益严重的公共卫生问题.
研究的目的:
- 评估野生加松鼠中抗菌素耐药性细菌的流行情况,特别是扩展谱β-乳糖酶 (ESBL) 生产的肠杆菌和金黄色葡萄球菌相关复合体.
- 为了描述这些松鼠的细菌群体.
- 调查野生动物和人类之间抗菌素耐药性的潜在传播途径.
主要方法:
- 分析了89只野生加松鼠的喉抽样.
- 选择性培养介质被用于ESBL生产的肠杆菌,黄金色杆菌相关复合体,阳性细菌和非发酵剂.
- 使用核心基因组多部位序列类型 (cgMLST) 的遗传学分析对产生ESBL的Enterobacterales进行.
主要成果:
- 鉴定出的主要细菌属是伪虫,型虫和阿克罗巴克特菌.
- 检测到三个产生ESBL的Klebsiella pneumoniae分离物和一个产生ESBL的Escherichia coli分离物.
- 这些产生ESBL的分离体与来自尼日利亚和加的人类分离体有着密切的遗传关系.
- 在采样的上没有检测到与金黄色葡萄球菌相关的复杂物.
结论:
- 野生松鼠可以被人类相关的ESBL产生的Klebsiella pneumoniae和Escherichia coli殖民.
- 这些发现表明,潜和人类之间或共同的环境来源之间可能存在传染.
- 这些耐药细菌在松鼠中的存在具有医学意义,特别是在食用野肉的地区.
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