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出生方式不能确定母体阴道微生物组和婴儿便微生物组之间共享的细菌菌株的存在
Scott J Dos Santos1, Ishika Shukla1, Janet E Hill1
1Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Microbiology spectrum
|June 20, 2023
概括
母亲的阴道细菌传染给婴儿是有限的,即使在阴道分娩. 其他母体来源,如肠道和母乳,可以补偿剖腹产产的婴儿缺乏阴道暴露.
科学领域:
- 微生物学 微生物学
- 新生儿健康 新生儿健康
- 人类微生物组研究研究
背景情况:
- 新生儿肠道微生物组失调与通过剖腹产产生的婴儿的疾病有关.
- 干预措施旨在通过将母亲的阴道微生物转移来纠正这一问题.
- 关于直接从母亲的阴道微生物传播给婴儿的知识有限.
研究的目的:
- 为了确定母体阴道细菌向婴儿垂直传播的程度.
- 调查婴儿便微生物组中是否存在母亲的阴道菌株.
- 了解婴儿的微生物来源,特别是通过剖腹产产生的婴儿.
主要方法:
- 使用cpn60微生物组分析.
- 采用基于培养的查和分子菌株类型.
- 进行了全基因组测序,用于母婴双菌株的菌株鉴定.
主要成果:
- 同样的cpn60序列变异在38.9%的母婴双中发现.
- 从一些二培养的同样的Bifidobacterium和Enterococcus物种.
- 无论传输方式如何,都检测到了几乎相同的菌株,这表明了替代来源.
结论:
- 母性阴道微生物群向新生儿的垂直传播可能是有限的.
- 其他母体部位 (肠道,母乳) 可能会弥补剖腹产婴儿缺少阴道暴露的情况.
- 在母亲和婴儿之间共享的相同菌株突出显示了早期生命中的替代微生物来源.
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