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Whole-body PET/MRI of Pediatric Patients: The Details That Matter
Published on: December 19, 2017
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患有淋巴瘤的儿童的FDG PET/MRI:MRI对比介质是否有所不同?
Kai Jannusch1, Janna Morawitz1, Bernd Schweiger2
1Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, Moorenstrasse 5, 40225, Dusseldorf, Germany.
European radiology
|June 20, 2023
概括
与对比度增强的MRI对使用[18F]FDG PET/MRI的儿童淋巴瘤患者进行分期没有额外的好处. 一个无对比的协议提供了准确的分期,可能减少副作用,时间和成本.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 核医学是一种核医学.
背景情况:
- 准确地确定儿科淋巴瘤的阶段对于治疗计划至关重要.
- FDG PET/MRI 结合了代谢和解剖成像来进行全面的评估.
- 在这种联合成像模式中,MRI对比剂的作用需要澄清.
研究的目的:
- 评估MRI对比剂在儿童淋巴瘤患者初级和随访分期的准确性上的影响.
- 为了确定没有对比的FDG PET/MRI协议是否足以进行分期.
- 评估减少与对比剂相关的不良影响,时间和成本的潜力.
主要方法:
- 对儿童淋巴瘤患者的105个FDG PET/MRI数据集进行了回顾性分析.
- 两种读取协议的比较:一种没有增强 (PET/MRI-1) 和一种具有对比增强 (PET/MRI-2).
- 根据国际儿科非霍奇金淋巴瘤分期系统 (IPNHLSS) 进行了分期,并对病原体学和后续成像进行了验证.
主要成果:
- 无论是PET/MRI-1还是PET/MRI-2,在86%的基于患者的分析中都实现了正确的分期 (90/105).
- 基于地区的分析显示,这两种方案的准确性都很高 (94%).
- 在对比度增强和不增强的协议之间,没有观察到敏感度,特异性或诊断准确性的显著差异.
结论:
- 核磁共振成像对比剂在使用FDG PET/MRI的儿科淋巴瘤患者的初级或随访分期中没有提供额外的诊断益处.
- 一个没有对比的FDG PET/MRI协议对于分期儿科淋巴瘤非常准确.
- 考虑一种无对比的协议可以提高患者的安全性,并简化检查过程.
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