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Updated: Jul 26, 2025

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在健康参与者的情绪调节范式下,管理对大脑活动的影响:功能磁共振成像研究

Pilar Artiach Hortelano¹, Marieke A G Martens^2,3,4, Abigail Pringle¹

¹Department of Psychiatry, University of Oxford, Oxford, UK.

Psychopharmacology

|June 20, 2023

概括

通过改变健康志愿者的大脑活动和连接性来影响情绪调节 (ER). 这项研究揭示了如何影响涉及管理负面情绪的神经通路,为双相情感障碍治疗提供了洞察力.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
药理学药理学是指药理学的学科.

背景情况:

情绪调节 (ER) 的困难是双相情感障碍 (BD) 的特征.
是BD的有效情绪稳定剂,但它对心理过程的确切作用机制尚不清楚.

研究的目的:

研究对健康志愿者的情绪调节 (ER) 的神经效应.
了解如何影响ER任务期间的大脑活动和连接.

主要方法:

这是一项双盲随机研究,涉及33名健康志愿者.
参与者接受了 (800毫克) 或安慰剂11天.
在治疗后的ER任务 (认知再评估) 中进行了fMRI扫描.

主要成果:

的使用降低了前额叶和侧额叶皮层的激活和前额-边缘连接.
增加了右上旋的活性,以及右中旋 (MTG) 与左中前旋之间的连接.
在情绪处理过程中,调节了杏仁体-额叶皮层连接和MTG介质前额叶皮层连接.

结论:

会影响与情绪调节有关的神经活动和连接性.
这些发现阐明了认知重新评估和的影响的神经支柱.
对双相情感障碍中的长期影响进行进一步的研究是有必要的,以开发改进的治疗方法.

关键词:

情感处理是一种情感处理.情绪调节情绪调节是的组成部分.任务 fMRI 的任务

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