在接受维持透析的狼患者中狼活动和结果
François Gaillard1,2, Delphine Bachelet3, Cécile Couchoud4
1Service de Transplantation, Néphrologie et Immunologie Clinique, Hôpital Edouard Herriot, Lyon, France.
Rheumatology (Oxford, England)
|June 20, 2023
概括
在维持透析 (MD) 开始后,治疗结束的狼患者比例增加. 然而,狼发作,心血管事件和感染仍然是一个重大问题,特别是在透析后的第一年.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 类风湿病学 类风湿病学
- 临床医学 临床医学
背景情况:
- 维护透析 (MD) 经常被认为可以减少狼活动.
- 有限的历史数据支持这一假设.
- 在开始透析的患者中,狼的自然史需要进一步阐明.
研究的目的:
- 在开始维持透析 (MD) 的患者中描述狼的自然史.
- 为了评估狼治疗状况的变化和透析开始后的疾病活动.
- 为了评估发作发作,心血管事件,感染的发生率,以及M.D.的狼患者的存活率.
主要方法:
- 使用REIN注册表对开始透析的狼患者 (2008-2011) 的回顾性队列研究.
- 5年的随访分析了国家卫生数据系统的医疗保健消费.
- 评估患者的"治疗结束" (≤5毫克/天的皮质类固醇,没有免疫抑制剂) 和累计发病率,心血管事件,感染,移植和生存.
主要成果:
- 包括137名狼患者 (121名女性,平均年龄42岁).
- "停止治疗"的比例从MD开始时的67.7%上升到3年后的83.4%.
- 狼发作主要发生在第一年 (51.6%不严重,11.6%严重);心血管事件 (42.2%) 和感染 (23.7%) 也在12个月后很常见.
结论:
- 狼治疗的减少在MD开始后被观察到,但爆发仍然存在,特别是在第一年.
- 在开始透析后,对狼患者进行持续的专家随访至关重要.
- 这项研究强调了在接受维持透析的患者中持续需要警性狼管理.
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