尼日利亚系统性红斑狼的模式:一项多中心描述性医院研究
Ojo Osaze1, Hakeem Babatunde Olaosebikan2, Abubakar Yerima3
1Kubwa General Hospital Abuja, Abuja, Nigeria.
Clinical rheumatology
|June 20, 2023
概括
系统性红斑狼 (SLE) 在尼日利亚并不罕见,主要影响30至40岁的女性. 这项研究强调了尼日利亚狼患者的延迟呈现和常见关节炎和皮肤问题.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,全球发病率可变.
- 之前关于尼日利亚SLE的报道有限,需要进行全面的国家研究.
研究的目的:
- 确定尼日利亚SLE患者的社会人口统计学,临床和实验室资料.
- 评估尼日利亚狼患者的治疗模式.
- 提供尼日利亚SLE流行和特征的国家数据.
主要方法:
- 一项多中心,回顾性,基于医院的研究在尼日利亚的20家风湿病诊所进行.
- 分析了896名SLE患者 (年龄≥18岁) 的数据,这些患者符合ACR 1997或SLICC 2012标准.
- 没有完整数据或其他类风湿性疾病的患者被排除在外.
主要成果:
- 该研究确定了896名SLE患者,平均年龄为34.47岁,女性与男性的比例为8.1.1:1.
- 在61.6%的患者中报告了关节炎 (关节炎),各种狼皮疹呈现.
- 抗核抗体 (ANA) 在98.0%的患者中呈阳性,通常具有高标位.
结论:
- 与之前的假设相反,SLE在尼日利亚并不罕见.
- 典型的尼日利亚SLE患者是女性,在她的第三到第四十年,呈现关节炎和粘膜皮肤问题.
- 有证据表明SLE频率存在种族差异,尼日利亚狼患者经常表现出高的ANA标位,在寻求专业护理方面存在明显的延迟.
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