特定的鼻科里尼细菌菌株作为防治SARS-CoV-2感染的守门员
Dora Szabo1,2, Eszter Ostorhazi3,4, Balazs Stercz3,4
1Institute of Medical Microbiology, Semmelweis University, Üllői Street 26, 1085, Budapest, Hungary. szabo.dora@med.semmelweis-univ.hu.
GeroScience
|June 20, 2023
概括
鼻微生物群,特别是Corynebacterium accolens,可能会降低SARS-CoV-2的易感性. 这些细菌降低病毒入口受体表达和S1-ACE2结合,表明益生菌的潜力.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 感染SARS-CoV-2的易感性因人而异.
- 鼻微生物组在这种敏感性中的作用尚未完全理解.
研究的目的:
- 为了研究鼻微生物组组成对SARS-CoV-2易感性的影响.
- 为了确定与感染风险降低相关的特定细菌物种.
主要方法:
- 16S rRNA测序和培养来自SARS-CoV-2暴露接触者的鼻样本.
- 培养的科里尼细菌的全基因组测序.
- 在Caco-2细胞中分析了ACE2,TMPRSS2,cathepsin L表达和S1-ACE2结合.
主要成果:
- 没有感染的个体在他们的鼻微生物群中表现出更高的Corynebacteria丰度.
- Corynebacterium accolens仅在未感染的个体中被发现.
- 科里尼细菌 (Corynebacterium spp.) 的一种. 降低了ACE2和cathepsin L表达的调节,并削弱了S1-ACE2结合,C. accolens显示了TMPRSS2表达的额外减少.
结论:
- 鼻中存在Corynebacterium spp.,特别是C. accolens,可能会对SARS-CoV-2感染产生抵抗力.
- 机制包括病毒进入受体的下调,S1-ACE2结合的抑制和脂酶的产生.
- C. accolens菌株显示出未来作为预防SARS-CoV-2感染的益生菌的潜力.
关键词:
在ACE-2中,ACE-2是最重要的.卡塞普辛L L L L L L L 卡塞普辛是什么意思科里尼细菌 (Corynebacterium accolensens) 已经被发现.鼻喉微生物组 鼻喉微生物组这就是SARS-CoV-2病毒.在TAG脂酶S1中.这就是TMPRSS2的原因.更多相关视频
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