胰腺区域血流连接了内分泌和外分泌疾病
Adam A Rizk1, Michael P Dybala1, Khalil C Rodriguez1
1Department of Medicine, The University of Chicago, Chicago, Illinois, USA.
The Journal of clinical investigation
|June 20, 2023
概括
胰腺血流可能是双向的,这挑战了长期以来的单向模型. 新的研究揭示了区域性血管化,表明小岛和外分细胞同时暴露于循环因素.
科学领域:
- 内分泌学 在内分泌学.
- 血管生物学 血管生物学
- 胰腺生理学 胰腺生理学
背景情况:
- 众所周知,内分泌和外分泌胰腺的疾病状态相互加剧.
- 这表明在小岛和外分细胞之间存在潜在的双向血流.
- 目前的模型假定从小岛到外分泌组织的单向血流,该模型于1932年建立,自此未经修订.
研究的目的:
- 在多种物种中研究胰腺小岛和血管之间的空间关系.
- 挑战已建立的单向胰腺血流的既定模型.
主要方法:
- 采用了大规模的图像捕捉.
- 在人类,子,猪,子,子和老鼠身上检查了小岛和血管的空间布局.
主要成果:
- 大多数小岛没有与动脉小管直接关联.
- 与动脉接触的小岛较大,数量较少.
- 动脉似乎供应整个胰腺区域,而不是单个小岛屿,这表明区域性血管化模式.
结论:
- 这些发现挑战了传统的单向胰腺血流模型.
- 区域血管化允许小岛和细胞同时暴露于系统因素.
- 这支持了内分泌和外分泌胰腺功能相互关联的概念.
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