温和的维生素C缺乏症在住院精神病患者中很常见
Bilal A Bari1,2, Ana Ivkovic1, Bryce A Wininger1
1Department of Psychiatry, Massachusetts General Hospital, Boston.
The Journal of clinical psychiatry
|June 20, 2023
概括
轻度维生素C缺乏症在精神病医院住院患者中很常见,影响64%的受试者. 即使其他营养风险因素有利时,这种高患病率仍然存在,这突显出严重的公共卫生问题.
科学领域:
- 营养精神病学 营养精神病学
- 临床营养学 临床营养学
- 心理健康研究 心理健康研究
背景情况:
- 轻微的维生素C缺乏会导致精神症状,如冷漠和疲劳.
- 完全缺乏是罕见的,但轻度形式在脆弱人群中持续存在.
- 精神病医院住院患者中轻度维生素C缺乏症的患病率尚未得到充分确立.
研究的目的:
- 为了确定在住院精神病患者中轻度维生素C缺乏症的患病率.
- 为了确定人口统计学,物质使用,诊断和微量营养素缺乏的风险因素.
- 评估叶酸和维生素D水平对维生素C状态的预测效用.
主要方法:
- 2015年1月至2022年3月期间,在221名住院患者的血维生素C水平分析.
- 包括人口,物质使用,诊断 (DSM-5-TR) 和微量营养素数据.
- 用于建模维生素C水平和风险因素的贝叶斯日志正常回归.
主要成果:
- 64%的患者 (141/221) 符合轻度维生素C缺乏的标准.
- 叶酸和维生素D水平是维生素C状态的强有力的预测指标.
- 模拟显示高预测缺陷 (50-55%),即使有足够的叶酸/维生素D.
结论:
- 维生素C缺乏症在住院精神病患者中非常普遍.
- 即使没有明显的共同风险因素,缺陷仍然存在.
- 对潜在原因和干预措施的进一步研究是有必要的.
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