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Updated: Jul 26, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
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Cu ((OTf) 2 增强的分子内核性2-氨基-3-烯诺林的化

Anwesha Bhattacharya1, Nayanthara Ramesh Babu1, Debashruti Bandyopadhyay1

  • 1School of Chemical Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, an OCC of Homi Bhabha National Institute, Khurda - 752050, Odisha, India.

The Journal of organic chemistry
|June 20, 2023
PubMed
概括

这项研究引入了一种新的双重异构注射策略,用于从简单的前体高效地合成印罗基诺林化物,包括neocryptolepine类似物. 该方法使用协同作用的铜催化N-arylation过程,快速获得良好的产量.

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Nucleophilic Aromatic Substitution: Elimination–Addition

Simple aryl halides do not react with nucleophiles. However, nucleophilic aromatic substitutions can be forced under certain conditions, such as high temperatures or strong bases. The mechanism of substitution under such conditions involves the highly unstable and reactive benzyne intermediate. Benzyne contains equivalent carbon centers at both ends of the triple bond, each of which is equally susceptible to nucleophilic attack. This 50–50 distribution of products is...
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