在軟骨動物Aplysia中對兩種Wamid神經型信號系統的分子特性Aplysia

Hui-Ying Wang1, Ke Yu1, Wei-Jia Liu1

  • 1State Key Laboratory of Pharmaceutical Biotechnology, Institute for Brain Sciences, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Advanced Institute for Life Sciences, Chemistry and Biomedicine Innovation Center, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210023, China.

PubMed
概括

研究人员在海洋软体动物Aplysia californica中描述了古老的Wamide信号系统,APGWamide (APGWa) 和肌抑制性 (MIP). 这项研究确定了受体和,揭示了它们的C端Wamide基因对活性至关重要.

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Synaptic Signaling

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Action Potentials01:41

Action Potentials

Overview
Synaptic Signaling01:09

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Action Potential01:14

Action Potential

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Action Potential01:14

Action Potential

Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...