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血和脑脊液的非酶蛋白损伤在阿尔茨海默病中持续存在
Farida Dakterzada1, Mariona Jové2, José Luís Cantero3
1Cognitive Disorders Unit, Clinical Neuroscience Research, Hospital Universitari Santa Maria, IRBLleida, Lleida, Spain.
Redox biology
|June 20, 2023
概括
血液和脑脊液中的氧化损伤标志物与阿尔茨海默病 (AD) 诊断或进展无关. 这表明与AD相关的氧化应激直接影响细胞,而不是通过这些液体.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 老年学是一门学科.
背景情况:
- 氧化压力与阿尔茨海默氏症 (AD) 病原发生有关.
- 对蛋白质的氧化损伤可能导致神经元功能障碍和AD的认知衰退.
- 关于阿尔茨海默病患者的全身和中央液体氧化损伤的研究有限.
研究的目的:
- 测量AD连续体内的血和脑脊液 (CSF) 中的非酶蛋白损伤.
- 评估蛋白质损伤标志物与从轻度认知障碍 (MCI) 到AD的临床进展之间的关系.
主要方法:
- 使用同位素稀释气体染色学――质谱学 (SIM-GC/MS) 在血和脑脊液中的量化非酶性蛋白质修饰标记.
- 研究了289名参与者:103人患有AD,92人患有MCI,94人对照.
- 对年龄,性别,APOE ε4等位基因和CSFAD生物标志物进行控制.
主要成果:
- 在对共变量进行控制后,血或脑液蛋白损伤标志物与AD或MCI诊断之间没有发现关联.
- 脊髓中蛋白质损伤标志物与脊髓中AD生物标志物没有相关性.
- 无论是血还是脑液蛋白损伤水平都与MCI与AD进展无关.
结论:
- 缺乏相关性表明,AD中的氧化损伤局部存在于细胞/组织水平.
- 细胞外液体标记物可能不能准确地反映体内氧化损伤,导致AD.
- 需要进一步的研究,以了解氧化应激在AD中的确切作用和位置.
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