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章酶抑制的目标是TP53突变的AML和AML干细胞/原始细胞

Bing Z Carter1, Po Yee Mak1, Muharrem Muftuoglu1

  • 1Department of Leukemia, Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.

Blood
|June 20, 2023
PubMed
概括

使用PU-H71准表层细胞,有效地杀死TP53突变性急性髓性白血病 (AML) 细胞和干细胞. 这种方法增强了venetoclax的活性,并防止TP53突变AML的耐药性.

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