一个新的VACTERL评估工具,以促进预期家庭的咨询
John S Riley1, John Schomberg2, Aditya Mantha3
1Center for Fetal Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA, john.riley@pennmedicine.upenn.edu.
Fetal diagnosis and therapy
|June 20, 2023
概括
这项研究开发了一种评估工具,用于VACTERL (脊椎,直肠,心脏,气管食道,脏和四肢) 缺陷. 该工具有助于提供者为家庭提供有关异常可能性和VACTERL综合征新生儿的结果的咨询.
科学领域:
- 医学研究 医学研究
- 儿科卫生保健 儿科卫生保健
- 有先天性异常.
背景情况:
- 瓦克特尔综合征是一种复杂的疾病,其特点是至少有以下三个先天性缺陷:脊椎,直肠,心脏,气管食道 (TE),脏和四肢.
- 对VACTERL综合征的诊断和管理给医疗保健提供者和家庭带来了重大挑战.
研究的目的:
- 为VACTERL综合征开发一个可访问的评估工具.
- 协助医疗保健提供者就诊VACTERL.L.的新生儿的潜在异常和结果向家庭提供咨询.
主要方法:
- 利用儿童住院患者数据库 (2003-2016) 来识别使用ICD-9-CM和ICD-10-CM代码的VACTERL新生儿.
- 应用多变量逻辑回归来估计住院患者的死亡率和Poisson回归来估计独特的VACTERL组合的住院时间.
主要成果:
- 在新生儿中,VACTERL综合征发生在0.016%的新生儿中;12.7%的新生儿在出院前死亡.
- 肢体异常,早产和低出生体重 (<1,750 g) 与死亡率增加有关.
- 心脏缺陷,脊椎异常,TE,直肠形和低出生体重与更长的住院时间有关.
结论:
- 开发了一种针对VACTERL综合征的新型评估工具.
- 这种工具有可能改善面临VACTERL诊断的家庭的咨询过程.
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