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Updated: Jul 26, 2025

Using In Vitro Fluorescence Resonance Energy Transfer to Study the Dynamics Of Protein Complexes at a Millisecond Time Scale
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对CAND1介导的SCF基质受体交换的结构和机制见解

Mohammed Shaaban1, Julie A Clapperton1, Shan Ding1

  • 1The Visual Biochemistry Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK.

Molecular cell
|June 20, 2023
PubMed
概括

人类CAND1蛋白促进SCF E3酶中基质受体的交换,这对细胞调节至关重要. 冷-EM揭示了CAND1和DCNL1如何相互作用以控制SCF复杂的动态和基质周转.

关键词:
在CAND1中.关于CRL的CRL是什么?在DCNL1 co-E3在SCF中,SCF是最重要的.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.库林-RING连接酶的作用没有脱,没有脱.基底受体的交换因子无处不在的信号传递

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