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使用生物三维打印机的无脚手架的人体血管化模型.

Yukiko Nagaishi1,2, Daiki Murata1, Hiromu Yoshizato1,3

  • 1Center for Regenerative Medicine Research, Faculty of Medicine, Saga University, Saga, Japan.

Biofabrication
|June 20, 2023
PubMed
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研究人员使用人类细胞开发了新的生物3D打印血管组织,以模拟Mönckeberg的模型.

科学领域:

  • 生物医学工程 生物医学工程
  • 血管生物学 血管生物学
  • 再生医学是一种再生医学.

背景情况:

  • 动脉样硬化相关的疾病对健康造成越来越大的负担.
  • 新型研究模型对于了解动脉样硬化和开发治疗方法至关重要.
  • 蒙克伯格中枢性硬化症是一种特定的血管化状况,需要更好的模型.

研究的目的:

  • 设计和评估生物3D打印的血管状管状组织作为一种新型研究模型.
  • 评估这些组织是否适合研究Mönckeberg的中间状硬化症.
  • 为了研究这些工程组织中的化过程.

主要方法:

  • 使用人类大动脉光滑肌细胞,内皮细胞和纤维细胞,对血管状管状组织进行生物3D打印.
  • 使用无机酸盐 (Pi) 或化培养印刷组织并刺激化.
  • 组织学评估,微计算机断层扫描 (micro-CT) 成像和基因表达分析 (RT-qPCR).

主要成果:

  • 生物3D打印的管状组织在长达3周的培养过程中表现出结构完整性.
  • 在存在化刺激因素的情况下,在培养1周内观察到化.
  • 微CT证实了沉积,RT-qPCR显示骨质转录因子的表达增加.
关键词:
动脉样硬化的模型生物3D打印机打印机没有脚手架的脚手架.血管化 血管化

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  • 皮和罗斯瓦斯塔丁的使用影响了组织化.

    • 结论:

    • 由人体细胞组成的生物3D打印的血管状管状组织代表了一个可行的新型研究模型.
    • 这些工程组织可以用于研究Mönckeberg的中间状硬化症.
    • 该模型允许研究化机制和潜在的治疗干预措施.